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LibraryHair Loss TreatmentsFinasteride, dutasteride, minoxidil
Last updated    | 7 minute read
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What is the best medication for hair loss?

Written by
XYON Medical Team
Clinically reviewed by
Dr. S. Pimstone, MD, PhD, FRCPC
Dr. C. Han, MD, FRCPC
Dr. V. Hasson, MD

Minoxidil and finasteride are the most popular active pharmaceutical ingredients (APIs) used for male pattern hair loss, or androgenetic alopecia (AGA).

Topical minoxidil and oral finasteride are both approved by the Food and Drug Administration (FDA) to treat AGA in biological men.

Dutasteride is a newer drug that works in the same way as finasteride to target hair loss. While dutasteride is not yet indicated as a treatment for hair loss in any form, this medication can be more effective than finasteride and minoxidil and has demonstrated promising results in clinical trials.

Each API works differently to stimulate hair growth and help restore your tresses. Below, you’ll find a basic overview of the top three medications for hair loss: finasteride, dutasteride and minoxidil.

Minoxidil

Minoxidil is the most widely recognized topical medication for hair loss. Minoxidil is the generic form of Rogaine™, an over-the-counter (OTC) drug that can be purchased at many retailers without a prescription.

Minoxidil drug development

Minoxidil was initially developed to treat high blood pressure. In clinical trials, improvements in hair count, density and volume were noted as a side effect of oral therapy (Badri et al. 2021). This observation spurred the development of a topical formulation for hair loss specifically. This modified dosage was largely intended to reduce the side effect profile of the drug and localize its effect within the scalp.

Minoxidil method of action

This medication’s exact mechanism of action is not entirely agreed upon, but there appear to be several ways in which minoxidil promotes hair growth.

Topical minoxidil has been associated with accelerated hair growth and improved circulation within the scalp. Countless clinical trials have demonstrated that this drug can shift hair into the anagen phase of the growth cycle prematurely, and extend the period of active growth (Gupta et al. 2021). Naturally, this shortens the telogen phase (when hair lies dormant and growth stagnates) as well as the exogen phase (when hair begins to shed). Prolonging active hair growth yields more mature terminal hairs, which are typically more pigmented and lend themselves to a fuller-looking head of hair.

The direct effects of minoxidil on scalp DHT (dihydrotestosterone) have been studied in a very limited capacity, but any conclusions are largely speculative. A very small body of data suggests that minoxidil may inhibit the function of androgen receptors within the scalp. The research does not support that minoxidil has an effect on DHT, however (Hsu et al., 2014).

Legal status of minoxidil

Minoxidil is currently the only drug approved by the FDA for the topical treatment of AGA.

While this drug could only be obtained by prescription until 1996, topical treatments containing minoxidil can now be purchased over-the-counter (OTC) at many retailers throughout Canada, the United States and Europe (FDA).

A topical solution containing minoxidil at 2% was first approved to treat male pattern hair loss by the FDA in 1988; the same formulation was endorsed as a treatment for female pattern hair loss in 1992 (FDA). Since then, a higher 5% concentration has been added to the roster of approved topical minoxidil formulations, and selection of foam and spray options have become available (Gupta et al. 2014).

Minoxidil side effects

Skin irritation is the most commonly reported side effect of minoxidil. Developing a rash, redness, scaling, dryness or itching is not uncommon.

The likelihood of experiencing side effects varies by formulation and from person to person. Foams and topical formulations containing a lower concentration of minoxidil are less likely to cause an adverse skin reaction.

More serious side effects of minoxidil include dizziness or lightheadedness, water retention and a sudden drop in blood pressure. These symptoms can indicate that the medication has entered the bloodstream and is being circulated throughout the body.

Thinning of the scalp skin has been noted as a side effect of prolonged treatment with minoxidil. Premature aging of the skin has also been suggested as a potential long-term side effect of the drug. Both of these long-term effects may be tied to minoxidil’s impact on an enzyme called lysyl hydroxylase. This particular enzyme plays an important role in collagen synthesis, which is critical to skin health (NIH).

Finasteride

Finasteride is the most effective pharmaceutical drug approved by the FDA to treat androgenetic hair loss.

Finasteride belongs to a class of drugs known as 5-alpha reductase inhibitors (5-ARIs) that target a root cause of hair loss in men: DHT. These drugs interfere with the synthesis of dihydrotestosterone (DHT) and aim to reduce the concentration of this hormone within the scalp.

Finasteride drug development

Finasteride was originally as an oral medication for benign prostatic hyperplasia (BPH), a medical condition that causes prostate enlargement. Hair growth was noted as a side effect in men undergoing treatment for BPH. A lower dosage of oral finasteride was developed to treat hair loss in men shortly thereafter.

A study conducted in 2009 demonstrated that topical finasteride formulations can produce results identical to an oral regimen (Hajheydari et al. 2009). These findings reflect a larger body of clinical data, which also supports that topical finasteride has less of an impact on serum testosterone and fewer side effects than oral finasteride.

Finasteride method of action

Finasteride and other 5-ARIs target an enzyme called 5-alpha reductase (5-AR), which breaks testosterone down into DHT. Elevated scalp DHT can cause premature hair loss, follicle shrinkage (called miniaturization) and left untreated, irreversible follicle death. Individuals with a genetic predisposition are typically more sensitive to even slight fluctuations in scalp levels of this hormone.

5-ARIs are competitive enzyme inhibitors. Finasteride and other drugs in this family attach to the 5-alpha reductase enzyme and prevent it from binding to testosterone.

This effectively reduces the amount of DHT being produced by the body. It lowers concentrations of DHT at the scalp to significantly reduce the attack on hair follicles and allows hair to experience greater growth.

The 5-AR enzyme has multiple structural variants, or isoenzymes. Finasteride inhibits type II only.

Finasteride legal status

Finasteride was first approved by the FDA as a prescription medication for BPH in 1992. In 1998, this drug was indicated in the treatment of pattern hair loss at a 1 mg/day oral dosage. At present, this is the sole dosage and form of finasteride endorsed by the FDA as a treatment for hair loss.

Topical finasteride is not approved by the FDA.

Any topical formulation containing finasteride is considered a compounded medicine. These custom drug formulations can only be obtained from select pharmacies.

Most topical finasteride formulations contain between 0.1-1% finasteride. Many are not are able to reduce the rate of penetration into the skin, but the data supports that select timed-release formulations can be compounded at up to 2.5% finasteride.

Finasteride side effects

Most individuals can use finasteride without experiencing any serious or long-term side effects. But as with any pharmaceutical drug, there is a chance that some will develop an adverse reaction to finasteride.

The following sexual side effects are most commonly associated with finasteride and other 5-ARIs:

  • Erectile dysfunction
  • Decreased sperm counts
  • Lowered libido
  • Difficulty experiencing an orgasm

Side effects are more likely to result from oral finasteride than topical, as circulation throughout the body is inevitable and drug action is generalized. Clinical and pharmacokinetic (PK) studies suggest that a lower proportion of the drug may be absorbed into the bloodstream via the skin, minimizing the impact on DHT throughout the body.

Dutasteride

Formulations containing dutasteride are novel, yet promising. The drug has been used for around 20 years to treat prostate enlargement and is sometimes prescribed off-label to treat hair loss.

Dutasteride drug development

Dutasteride is another medication that was initially used to treat BPH in biological men and was incidentally found to generate hair growth. The positive impact on hair quality and quantity sparked interest in the use of this drug to treat hair loss caused by increased DHT levels at the scalp.

Dutasteride method of action

Like finasteride, this medication is a 5-alpha reductase inhibitor. It prevents the synthesis of DHT and lowers concentrations of this androgen at the scalp, targeting hair loss at the site. Dutasteride is considered the most effective medicine in its drug class, targeting both 5-AR types I & II.

A recent literature review determined that in most clinical studies to date, an oral dosage successfully reduced scalp and serum DHT levels in men with hair loss (Zhou et al. 2020). Research suggests that dutasteride is more effective at generating hair growth and decreasing the number of fine vellus hairs on the scalp even more effectively than oral finasteride (Shanshanwal and Dhurat, 2017).

Dutasteride legal status

Therapeutic use of this medication for male pattern hair loss is currently in the investigative stages. Most clinical studies have set out to determine the safety and efficacy of dutasteride for pattern hair loss at a dosage of 0.5mg taken orally. A 1mg oral dosage has been used to treat BPH.

At present, hair loss is not an approved indication for any oral dutasteride dosage or topical formulation containing this drug.

Dutasteride side effects

Potential adverse effects of dutasteride use are still under investigation, though sexual side effects similar to those associated with finasteride have been noted.

There is speculation that the potential risk of side effects is greater with dutasteride than its close relative, finasteride. Dutasteride's two-pronged attack against the 5-AR enzyme may amplify the drug's effect; this is especially true when it has gone systemic.

The take-home

Finasteride, minoxidil and dutasteride are pharmaceutical drugs. The varying side effect profiles, methods of actions and effectiveness of each drug should be taken into consideration by the prescribing physician.

There’s no one-size-fits-all when it comes to medical treatments targeting androgenetic hair loss. The suitability of each drug should be evaluated by a physician, on a case-by-case basis before making a prescription.


References

Andrea Leonard-Segal, MD, Acting Director. (2006). Medical Review - Men’s Rogaine Extra Strength 5% Minoxidil Foam. Center for Drug Evaluation and Research. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021812s000_MedR.pdf

Badri, T., Nessel, T. A., & Kumar D, D. (2021). Minoxidil. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK482378/

Bryan, J. How minoxidil was transformed from an antihypertensive to hair-loss drug. The Pharmaceutical Journal. https://pharmaceutical-journal.com/article/news/how-minoxidil-was-transformed-from-an-antihypertensive-to-hair-loss-drug

Frye, S. V. (2006). Discovery and clinical development of dutasteride, a potent dual 5alpha-reductase inhibitor. Current Topics in Medicinal Chemistry, 6(5), 405–421. https://doi.org/10.2174/156802606776743101

Marihart, S., Harik, M., & Djavan, B. (2005). Dutasteride: A Review of Current Data on a Novel Dual Inhibitor of 5α Reductase. Reviews in Urology, 7(4), 203–210. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550785/

Minoxidil. (2018, July 26). ISHRS. https://ishrs.org/patients/treatments-for-hair-loss/medications/minoxidil/

Rossi, A., Cantisani, C., Melis, L., Iorio, A., Scali, E., & Calvieri, S. (2012). Minoxidil use in dermatology, side effects and recent patents. Recent Patents on Inflammation & Allergy Drug Discovery, 6(2), 130–136. https://doi.org/10.2174/187221312800166859

Shanshanwal, S. J. S., & Dhurat, R. S. (2017). Superiority of dutasteride over finasteride in hair regrowth and reversal of miniaturization in men with androgenetic alopecia: A randomized controlled open-label, evaluator-blinded study. Indian Journal of Dermatology, Venereology and Leprology, 83(1), 47–54. https://doi.org/10.4103/0378-6323.188652

Suchonwanit, P., Thammarucha, S., Leeranyakul, H. Minoxidil and its use in hair disorders. Drug Design, Development and Therapy. 2019; 13: 2777–2786. 2019 Aug 9. 10.2147/DDDT.S214907

Zhou, Z., Song, S., Gao, Z., Wu, J., Ma, J., & Cui, Y. (2019). The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis. Clinical Interventions in Aging, 14, 399–406. https://doi.org/10.2147/CIA.S192435


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